Ms. Gladstone, who ran one of New York City’s largest contemporary art galleries, died last year. Her friend, the architect Annabelle Selldorf, helped her renovate the home.

The Greek Revival rowhouse at 344 West 22nd Street looks much like the neighboring 19th-century brick homes, which are all part of the Chelsea Historic District. But inside it’s clearly contemporary.

Barbara Gladstone bought the home in 2011, then spent the next couple of years on renovations.Chang W. Lee/The New York Times

The house, stylishly renovated with the help of the architect Annabelle Selldorf, was the home of the art gallerist Barbara Gladstone, who died last year at age 89. Ms. Gladstone, who specialized in contemporary art, bought the building in 2011 for $6.3 million, above the asking price, then spent the next couple of years revamping the space.

The main entrance is on the parlor level, where there is a front sitting room and formal dining area.Hayley Ellen Day

The home’s white plaster walls are bedecked in modern artwork, surrounded by avant-garde sculptures. A sinuous, sky-lit staircase sits at the home’s center, next to an elevator, while an updated rear facade features floor-to-ceiling casement windows that provide ample light for the eye-catching pieces.

It is now back on the market by her estate with an asking price of $11.995 million, according to Scott Hustis, a broker at Compass who is listing the property with his colleague Mark Jovanovic. Annual property taxes are $44,027.